大动脉反对左心室应变和重塑的额外影响在使用MRI评估的基本高血压患者中
Wei-Feng Yan1, Zhi-Gang Yang1, Xue-Ming Li1
1Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Journal of magnetic resonance imaging : JMRI
|November 15, 2023
概括
大动脉反 (AR) 显著损害左心室 (LV) 应变,并增加高血压患者的LV质量. 增加AR严重程度与心脏功能恶化和结构变化相关.
科学领域:
- 心脏病学 心脏病学
- 医疗成像医学成像
- 高血压研究 高血压研究
背景情况:
- 大动脉反 (AR) 对心脏健康构成重大风险,特别是在患有高血压的患者中.
- 了解AR对左心室 (LV) 的特定影响对于管理高血压患者至关重要.
研究的目的:
- 在高血压患者中评估左心室 (LV) 应变和结构.
- 在这个人群中确定大动脉反 (AR) 和LV变化的严重程度之间的关系.
主要方法:
- 一项追溯性研究涉及263名高血压患者和62名对照患者,使用心脏MRI.
- 在3.0T时使用平衡稳定状态自由前行 (bSSFP) 序列的心脏MRI用于评估LV几何和应变.
- 通过心声学对AR的严重程度进行了分类,而LV心肌菌株 (GRPS,GCPS,GLPS) 和LVMI则通过MRI后处理量化.
主要成果:
- 与没有AR的高血压患者相比,AR的高血压患者表现出显著减少的LV心肌压和升高的LVMI.
- 在AR严重程度和LV全球辐射,周围和纵向峰值应变的绝对值之间观察到显著的负相关性.
- 随着AR严重程度的升级,LV异常增高的患病率显著增加,并且确定了AR作为影响LV菌株和LVMI的独立因素.
结论:
- 大动脉反的严重程度增加与高血压患者的心脏功能减弱和左心室几何重塑的不良影响有关.
- 这些发现突显了AR对高血压心脏的有害影响,并强调需要仔细监测和管理.
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