认知症状随着临界主导的与年龄相关的TDP-43脑病变阶段以及与阿尔茨海默病同时发生的认知症状的进展
Satomi Hiya1, Carolina Maldonado-Díaz1, Jamie M Walker1,2,3
1Department of Pathology, Molecular and Cell-Based Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.
Journal of neuropathology and experimental neurology
|November 15, 2023
概括
临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 和阿尔茨海默氏症.
科学领域:
- 神经病理学神经病理学
- 神经退行性疾病 神经退行性疾病
- 认知神经科学 认知神经科学
背景情况:
- 临主导的与年龄相关的TDP-43脑病变神经病理变化 (LATE-NC) 是一个独特的神经病理.
- 晚期NC与阿尔茨海默病的神经病理变化 (ADNC) 的临床和病理重叠.
- 了解LATE-NC单独和ADNC的认知影响对于诊断和管理至关重要.
研究的目的:
- 调查孤立和并发LATE-NC和ADNC的认知影响.
- 确定与LATE-NC和ADNC进展相关的认知障碍的独立风险.
主要方法:
- 来自国家阿尔茨海默氏症协调中心的认知/神经心理,神经病理,遗传和人口统计数据的分析.
- 包括28个对照,31个孤立的LATE-NC,244个孤立的ADNC和172个并发的LATE-NC/ADNC受试者.
- 多变量逻辑回归用于评估认知障碍的独立风险.
主要成果:
- 无论是LATE-NC还是ADNC都会对认知产生负面影响,其影响随神经病理阶段的升级而升级.
- 同时的LATE-NC和ADNC病例表现出最严重的认知障碍.
- 渐进的LATE-NC阶段 (OR 1.66) 和ADNC水平 (OR 3.41) 独立地与认知障碍相关.
结论:
- 晚期NC病理显著导致认知障碍,独立于ADNC.
- 晚期NC和ADNC的同时出现导致最深刻的认知缺陷.
- 这些发现突显了LATE-NC的临床意义以及混合病理对认知衰退的影响.
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