长期使用阿司匹林和癌症风险:20年的队列研究
Charlotte Skriver1, Thomas Maltesen1, Christian Dehlendorff1
1Danish Cancer Institute, Danish Cancer Society, Copenhagen, Denmark.
Journal of the National Cancer Institute
|November 15, 2023
概括
长期使用低剂量阿司匹林显示了许多癌症的风险降低,但总体而言并非如此,因为对一些癌症的风险增加. 使用高剂量的阿司匹林显示出更强的抗癌保护作用.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 阿司匹林使用与降低结肠直肠癌风险有关,但其对其他癌症的影响尚不清楚.
- 这项研究调查了丹麦长期使用阿司匹林与癌症风险之间的关联.
研究的目的:
- 检查低剂量和高剂量阿司匹林使用与整体和特定部位癌症的风险之间的关联.
- 评估阿司匹林连续性,持续时间和累积剂量对癌症风险的影响.
主要方法:
- 从1997年到2018年,全国范围的注册数据跟踪了40-70岁的个人.
- 根据低剂量 (75-150毫克) 和高剂量 (500毫克) 的阿司匹林使用,考克斯回归分析估计了癌症诊断的危险比率.
- 根据持续性,持续时间和累积量来评估阿司匹林的使用情况.
主要成果:
- 低剂量阿司匹林并没有降低整体癌症风险 (HR=1.04).
- 长期使用低剂量阿司匹林 (≥5或≥10年) 降低了结肠,直肠,食道,胃,肝脏,胰腺,小肠,头,大脑,脑膜瘤,黑色素瘤,甲状腺,非霍奇金淋巴瘤和白血病的风险.
- 肺癌和膀癌的风险增加;高剂量阿司匹林使用显示整体癌症风险降低 (HR=0.89).
结论:
- 长期使用低剂量阿司匹林可以适度降低特定癌症的风险,但不能降低整体癌症风险.
- 持续使用高剂量阿司匹林表明与癌症风险有类似或更强的反向关联.
- 这些发现突出了阿司匹林剂量和持续时间对不同类型癌症的不同影响.
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