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在转移性黑色素瘤中使用或不使用免疫治疗的放射治疗:疗效和耐受性

Ellen Backlund^1,2, Vitali Grozman^3,4, Suzanne Egyhazi Brage²

¹Department of Oncology, Karolinska University Hospital, Stockholm, Sweden.

Acta oncologica (Stockholm, Sweden)

|November 15, 2023

概括

将放射治疗 (RT) 与免疫检查点抑制剂 (ICI) 结合起来,可显著改善转移性黑色素瘤患者的抗瘤反应. 这种组合治疗,即使在疾病进展时开始,与单独RT相比,也显示出更高的疗效,从而导致更好的生存结果.

科学领域:

在瘤学瘤学.
免疫治疗是一种免疫疗法.
辐射瘤学辐射瘤学

背景情况:

放射治疗 (RT) 通常用于缓解转移性黑色素瘤.
免疫检查点抑制剂 (ICI) 可以增强抗瘤免疫反应.
RT和ICI的组合可能会诱导腹膜效应,影响远程转移.

研究的目的:

评估RT与ICI在转移性黑色素瘤中结合的疗效.
为了比较在治疗开始时启动的RT加ICI的结果与在治疗进展时的结果.
评估组合疗法对abscopal效应和生存益处的评估.

主要方法:

在斯德哥尔摩 (2015-2020年) 接受非立体治疗的转移性黑色素瘤患者的回顾性研究.
患者被分为:RT + ICI (起始),RT + ICI (救援) 和RT (仅限).
评估的反应率 (照射和非照射),生存率和毒性.

主要成果:

组合疗法 (RT + ICI) 在照射病变 (70.7%和67.5%) 和单独RT (43.1%) 中显示出更高的响应率.
与RT单独 (0.0%) 相比,RT+ICI组的非辐射病变的整体应答率显著更高 (36.1%和14.8%).
组合治疗 (18.2个月和15.0个月) 与单独RT治疗 (7.2个月) 的平均整体存活时间明显较长.

结论:

接受RT结合ICI的转移性黑色素瘤患者表现出优异的抗瘤反应和生存率.
即使在进展 (救援) 时启动RT加ICI,也会产生显著的益处,包括腹膜效应.
在所有治疗组中,RT的局部反应与改善的生存率相关.

关键词:

黑色素瘤是一种黑色素瘤.这是一种abscopal效应.免疫疗法免疫疗法放射性免疫疗法是一种放射性免疫疗法.辐射疗法辐射疗法

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