相关实验视频
Updated: Jul 11, 2025

07:01
An Orthotopic Mouse Model of Anaplastic Thyroid Carcinoma
Published on: April 17, 2013
21.1K
BRAF对淋巴结转移在乳头甲状腺癌与哈希莫托甲状腺炎中的影响和相互作用
Pengyu Li1,2, Yang Liu1, Tao Wei1,2
1Division of Thyroid Surgery, Department of General Surgery, West China Hospital, Sichuan University, Wuhou District, Chengdu 610044, China.
The Journal of clinical endocrinology and metabolism
|November 15, 2023
概括
B-Raf原型瘤基因 (BRAF) 突变是与哈希莫托甲状腺炎 (HT) 相关的乳头甲状腺癌 (PTC) 淋巴结转移的危险因素. BRAF与BMI和高血压等因素相互作用,影响转移.
科学领域:
- 在瘤学瘤学.
- 遗传学 遗传学 是一个
- 内分泌学 在内分泌学.
背景情况:
- B-Raf原瘤基因 (BRAF) 在乳头甲状腺癌 (PTC) 与哈希莫托甲状腺炎 (HT) 同时发生的作用尚不清楚.
- 了解这些遗传和临床相互作用对于预测疾病进展至关重要.
研究的目的:
- 调查PTC患者的淋巴结 (LN) 转移的风险因素.
- 探索BRAF突变对LN转移的相互作用效应,在这个患者队列中.
主要方法:
- 对994名患有HT的PTC患者的回顾性分析.
- 术前特征和LN转移之间的相关性分析,按BRAF V600E突变状态分层.
- 后勤回归和相互作用效应分析以确定风险因素和BRAF相互作用.
主要成果:
- 整体LN转移率为52.71%. BRAF的突变率为26.9%. 这种突变的发生率很高.
- BRAF突变与较高的LN转移率 (31.7%对21.5%,P <.001) 有意义地相关.
- 确定了LN转移的多种风险因素,包括BRAF突变,BMI,高血压和瘤特征,BRAF和BMI,高血压,最大直径和化之间的显著相互作用.
结论:
- 在HT的PTC中,BRAF突变是淋巴结转移的重要危险因素.
- BRAF与年龄,BMI,高血压和化等临床因素相互作用,共同影响LN转移风险.
相关概念视频
Synthesis and Regulation of Thyroid Hormones
4.7K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
4.7K
Functions of Thyroid Hormones
2.8K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
2.8K
mTOR Signaling and Cancer Progression
3.8K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.8K
Intracellular Signaling Affects Focal Adhesions
2.7K
Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
Some...
2.7K
Targeted Cancer Therapies
7.7K
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
There are several types of targeted therapies against...
7.7K

