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Updated: Jun 30, 2026

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深度学习预测急性髓性白血病中的治疗相关遗传学,来自帕海姆染色骨髓涂抹

Jacqueline Kockwelp1,2,3, Sebastian Thiele1,2, Jannis Bartsch4

  • 1Institute for Geoinformatics, University of Münster, Münster, Germany.

Blood advances
|November 15, 2023
PubMed
概括

一个新的深度学习管道从骨髓细胞图像直接预测急性髓性白血病 (AML) 的遗传异常. 这种具有成本效益的工具通过快速识别关键的遗传改变,有助于早期治疗决策.

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Genetic polymorphisms in drug targets have emerged as critical determinants of interindividual variability in drug response and toxicity. Pharmacogenomic investigations increasingly focus on identifying these variations to personalize and optimize therapeutic interventions. A drug target may be a receptor, enzyme, or signaling protein involved in pharmacologic responses or disease-related pathways. While early pharmacogenetic studies focused primarily on drug metabolism, current research...