隐形眼镜具有pH敏感度,可在佩戴的情况下按需释放药物
Jong Ryeol Kim1, So Young Kim1, Hosu Kang1
1Department of Polymer Science and Engineering, Polymeric Nano-Materials Laboratory, Kyungpook National University, Daegu 41566, South Korea.
ACS applied bio materials
|November 15, 2023
概括
这项研究介绍了一种新的pH敏感隐形眼镜,用于眼部疾病的按需药物输送. 创新的设计可以防止过早的泄漏,确保在磨损过程中控制治疗释放.
科学领域:
- 眼科药物输送系统 眼科药物输送系统
- 生物材料科学是生物材料的科学.
- 纳米技术用于医学.
背景情况:
- 释放药物的隐形眼镜为眼部疾病提供了治疗潜力.
- 目前的限制包括不受控制的药物释放和过早泄漏.
- 精确控制药物释放时间和剂量仍然是一个挑战.
研究的目的:
- 开发一种pH敏感的隐形眼镜,用于按需释放药物.
- 在包装和运输过程中尽量减少药物过早泄漏.
- 为了确保在透镜佩戴期间控制治疗.
主要方法:
- 将含有药物的半孔纳米颗粒 (MSN) 涂上 pH 敏感聚合物,将其纳入隐形眼镜中.
- 使用具有较低临界溶液温度 (LCST) 的pH敏感聚合物,该温度随pH而变化.
- 在模拟透镜磨损 (酸性pH,35°C) 和储存条件 (中性pH,低温) 下研究药物释放特征.
主要成果:
- 对pH敏感的隐形眼镜仅在35°C的酸性条件下 (pH ~6.5) 显示持续的药物释放,模仿镜头磨损.
- 在中性pH值或低温条件下观察到微不足道的药物泄漏,模拟包装和运输.
- 开发的隐形眼镜保持了必不可少的散装特性 (光学,机械,物理) 并表现出良好的生物相容性.
结论:
- 对pH值敏感的隐形眼镜有效地实现按需释放药物,并防止过早泄漏.
- 该系统为控制眼部药物输送提供了一个有前途的平台.
- 该技术在治疗各种眼部疾病方面具有潜在的应用.
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