橄油提取物与氧醇丰富的短期影响心血管功能
Nikolaos Iakovis1, Ignatios Ikonomidis2, Ioanna Andreadou3
1Department of Cardiology, University Hospital of Larissa, Larissa, Greece.
Journal of medicinal food
|November 15, 2023
概括
富含氧醇 (HT) 的橄油提取物在冠状动脉疾病 (CAD) 患者中显示了改善心脏功能和动脉弹性的趋势. 需要进一步的研究来证实这些有希望的心血管益处.
科学领域:
- 心脏病学 心脏病学
- 营养科学 营养科学
- 药理学 药理学是指药理学的学科.
背景情况:
- 橄油中的多,如氧醇 (HT),具有已知的抗氧化和抗炎性质.
- 慢性冠状动脉疾病 (CAD) 影响心脏和血管功能.
- 研究心血管健康的天然化合物至关重要.
研究的目的:
- 评估氧醇丰富橄油提取物 (OE) 对慢性CAD患者心脏和动脉特性的短期影响.
- 评估左心房和左心室 (LV) 功能中的变化.
- 为了确定对动脉弹性特性的影响.
主要方法:
- 一项随机,两期,两序交叉研究,涉及61名慢性CAD患者.
- 参与者每天接受OE囊 (500mg,5mgHT) 或安慰剂,持续30天,然后在48小时的洗后进行交叉治疗.
- 用心声/多普勒和平面度计进行评估.
主要成果:
- 没有观察到LV喷射率或中央大动脉压力的显著变化.
- 观察到 LV 扩张功能 (E/e) 的改善趋势 (P=.062).
- 观察到改善动脉弹性特性 (脉冲波速度) 的趋势 (P=.091).
结论:
- 在慢性CAD患者中,短期使用富含HT的OE显示出改善LV透静功能和大动脉弹性的趋势.
- 这些发现表明,富含HT的橄油提取物对心血管有潜在的益处.
- 长期研究是有必要的,以证实这些影响,并探索临床结果.
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