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Updated: Jul 11, 2025

Author Spotlight: Characterizing DNA G-Quadruplex by Bis-3-Chloropiperidine Based Chemical Mapping
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一个域选择性主体和额外终端N终端主体化学探测器的结构导向设计

Erin Bradley1,2, Lucia Fusani1,2, Chun-Wa Chung1

  • 1GSK, Medicines Research Centre, Stevenage SG1 2NY, Hertfordshire, U.K.

Journal of medicinal chemistry
|November 15, 2023
PubMed
概括

研究人员开发了一种新的化学探针,GSK023,准了原蛋白和额外终端 (BET) 蛋白家族. 这种探针对BET原蛋白1 (BD1) 具有很高的选择性,促进了免疫-炎症和瘤疾病研究.

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Labeling DNA Probes03:31

Labeling DNA Probes

DNA probes are fragments of DNA labeled with a reporter tag to enable their detection or purification. The resulting labeled DNA probes can then hybridize to target nucleic acid sequences through complementary base-pairing, and may be used to recover or identify these regions.
Radioisotopes, fluorophores, or small molecule binding partners like biotin or digoxigenin, are the most widely used reporter tags for labeling DNA probes. These labels can be attached to the probe DNA molecule via...
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