活跃癌症患者的COVID-19:较高的炎症活动预示着较差的结果
Maria Madeleine Rüthrich1,2,3,4, Yascha Khodamoradi5, Julia Lanznaster6
1Department of Interdisciplinary Intensive Care Medicine, Humboldt-Hospital Vivantes Berlin, Berlin, Germany.
Oncology research and treatment
|November 15, 2023
概括
与非活跃癌症患者相比,活跃癌症患者的COVID-19死亡率更高. 像费里丁和CRP这样的炎症标志物升高与活跃癌症患者的严重结局有关.
科学领域:
- 在瘤学瘤学.
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 活跃恶性瘤是严重COVID-19的已知风险因素之一.
- 有限的数据存在,比较了COVID-19患者的结果,有活跃与非活跃的癌症.
研究的目的:
- 为了比较COVID-19在患有活跃恶性瘤的癌症患者中的严重程度和死亡率与患有非活跃癌症的癌症患者.
- 为了确定这些患者群体中严重的COVID-19和死亡率的预测因素.
主要方法:
- 对987名PCR确认的SARS-CoV-2感染的癌症患者进行了回顾性分析.
- 收集的数据包括人口统计,癌症状况和实验室发现.
- 进行了描述性和回归分析,以评估严重的COVID-19和死亡率等结果.
主要成果:
- 在患有活跃癌症 (24%) 的患者中,与非活跃癌症 (17.5%) 相比,COVID-19相关死亡率显著更高.
- 铁素和C反应蛋白 (CRP) 的升高与活跃癌症患者的严重程度和死亡率的增加有关.
- 费里丁也与非活跃癌症患者的不良结果有关.
结论:
- 患有活跃癌症的患者在感染SARS-CoV-2时死亡率较高.
- 炎症增加,由费里丁和CRP等标记物表明,在活跃癌症患者的COVID-19不良结果中起着重要作用.
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