早期发生的结肠癌显示出明显的肠道微生物组和宿主-微生物相互作用
Darbaz Adnan1, Jonathan Q Trinh2, Deepak Sharma1
1Rush Center for Integrated Microbiome and Chronobiology Research, Rush Medical College, Rush University Medical Center, Chicago, Illinois.
Cancer prevention research (Philadelphia, Pa.)
|November 15, 2023
概括
肠道的微生物群.
科学领域:
- 微生物组研究的研究.
- 癌症生物学 癌症生物学
- 胃肠病学 胃肠病学
背景情况:
- 结肠直肠癌的发病率在年轻人中正在增加.
- 生活方式的改变和环境暴露是潜在的驱动因素.
- 肠道微生物组在早期结直肠癌中的作用尚不清楚.
研究的目的:
- 研究结直肠癌患者肠道微生物组的与年龄相关的差异.
- 为了比较早期和晚期结直肠癌之间的便和瘤微生物组.
- 探索不同年龄段的微生物与宿主相互作用.
主要方法:
- 对公开可用的便中遗传基因组学数据 (CuratedMetagenomeData,TCGA) 的分析.
- 在单独的患者队列中检查与瘤相关的微生物组.
- 集成宿主基因表达数据.
主要成果:
- 微生物特征在结直肠癌中显示出明显的年龄相关差异.
- 在早期发病 (<50岁) 和晚期发病 (>65岁) 患者之间,物种丰富度有所不同.
- 瘤微生物组分析证实了特定年龄的分类群丰度差异.
- 在早期发病的结直肠癌中观察到更强的微生物与宿主相互作用.
结论:
- 在结直肠癌中,肠道微生物组的组成取决于年龄.
- 微生物与宿主之间的相互作用在早期发作的瘤中更为明显.
- 微生物可能通过途径相互作用在年轻患者的瘤发生中发挥直接作用.
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