PD1+ TIGIT+2B4+KLRG1+ 细胞可能是治疗BCMA导向化学抗原受体T细胞疗法患者的T细胞功能障碍的基础

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Updated: Jul 11, 2025

Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography
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Dynamic Imaging of Chimeric Antigen Receptor T Cells with [18F]Tetrafluoroborate Positron Emission Tomography/Computed Tomography

Published on: February 17, 2022

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Ameet K Mishra1, Timothy M Schmidt1, Ella B Martell1

  • 1Department of Medicine, Division of Hematology and Oncology, School of Medicine and Public Health, University of Wisconsin, Madison, Wisconsin.

Transplantation and cellular therapy
|November 15, 2023
PubMed
概括

卡特-T疗法对复发性/耐药性多发性骨髓瘤 (RRMM) 是有前途的,但复发很常见. 这项研究揭示了在RRMM和后CAR-T复发患者中明显的T细胞表型和增加的共抑制标记,表明T细胞内在因素有助于抵抗.

关键词:
抗BCMA的CAR-T可以使用.硬币的抑制标记物多发性骨髓瘤是一种多发性骨髓瘤.PD1 ((+) TIGIT ((+) 2B4 ((+) KLRG1 ((+)) 在这个问题上.这种T细胞功能障碍是什么?T细胞内在因素是T细胞内在因素.

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