产后的炎症反应需要MyD88并由母亲和后代驱动
Jennifer M Gray1, Kharli Major1, Alexandra Castillo-Ruiz1
1Neuroscience Institute, Georgia State University, Atlanta, GA 30303, USA.
Brain, behavior, and immunity
|November 15, 2023
概括
新生儿出生时的炎症反应依赖于母体和后代的骨髓分化初级反应88 (MyD88) 信号. 母亲的MyD88状态显著影响新生儿的大脑微质细胞和神经元细胞死亡.
科学领域:
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
- 发展生物学 发展生物学
背景情况:
- 出生是新生儿的炎症事件,涉及细胞因子激增和微质变化.
- 驱动这些炎症反应的精确机制及其细胞起源仍然不清楚.
- 收费类受体 (TLR) 和它们的适配器神经分化初级反应88 (MyD88) 是先天免疫的关键.
研究的目的:
- 调查MyD88信号传递在调解新生儿出生炎症反应中的作用.
- 为了确定MyD88依赖的炎症信号是否发生在后代,母亲或两者之间.
- 阐明母亲和后代MyD88状态对围产期炎症和神经发育的具体贡献.
主要方法:
- 在母体和后代中利用了基因改造的小鼠,具有不同的MyD88基因状态.
- 在周产期测量了血细胞因子水平 (IL-6,IL-10,TNF-α).
- 评估脑细胞因子表达,微质密度和后代的神经细胞死亡.
- 分析了母乳中的细胞因子含量.
主要成果:
- 周产期IL-6和TNF-α在后代中的激增仅取决于后代的MyD88状态.
- 产后IL-10和TNF-α的增加需要母体和后代的MyD88信号.
- 母亲MyD88基因型显著影响后代大脑微质密度和发育神经元细胞死亡.
- 牛奶细胞因子被检测到,但不需要MyD88来检测它们的存在.
结论:
- 产后的炎症反应严重依赖于MyD88信号传递,涉及母体和后代的通路.
- 后代的MyD88对早期周围炎症至关重要,而母体和后代的MyD88都对后来的炎症反应有所贡献.
- 母亲MyD88在调节后代神经发育方面发挥着主要作用,包括微质密度和神经细胞死亡,独立于牛奶细胞因子.
关键词:
出生 出生 出生 出生 出生 出生 出生 出生细胞死亡 细胞死亡细胞因子 (cytokines) 是一种细胞因子.微质细胞中的微质细胞牛奶 牛奶 牛奶 牛奶我的D8888是什么意思神经炎症是一种神经炎症.分割的方法 分割的方法收费类受体的收费类受体.更多相关视频
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