与创伤性压力相关的细胞和认知衰老的纵向研究
Erika J Wolf1, Mark W Miller1, Sage E Hawn2
1National Center for PTSD at VA Boston Healthcare System, Boston, MA, USA; Boston University Chobanian & Avedisian School of Medicine, Department of Psychiatry, Boston, MA, USA.
Brain, behavior, and immunity
|November 15, 2023
概括
创伤性压力和外部化行为加速表观遗传衰老 (GrimAge),导致老兵的神经病理生物标志物增加和认知能力下降. 先进的灰色年龄将精神病并发症与未来的神经退行风险联系起来.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
背景情况:
- 创伤性压力与表观遗传衰老加速和痴呆症风险增加有关.
- 加速表观遗传年龄可能会调解创伤症状和痴呆症生物标志物之间的关系,如粉样蛋白-β (Aβ) 和神经纤维光 (NFL).
研究的目的:
- 为了研究创伤性压力,表观遗传衰老 (GrimAge),神经病理生物标志物和遭受创伤的退伍军人的认知功能之间的纵向关联.
- 测试加速表观遗传年龄将精神病并发症与随后的神经病理学和认知衰退联系在一起的假设.
主要方法:
- 对214名遭受创伤的退伍军人进行了长度研究,在5.6年内进行了两次评估.
- 交叉滞后的面板调解模型分析了终身创伤后应激障碍,并发性疾病,GrimAge表观遗传年龄和血生物标志物 (Aβ-40,Aβ-42,NFL,IL-6,GFAP).
- 神经认知任务评估工作记忆,执行/注意控制和口头记忆.
主要成果:
- 外向性并发症与加速的GrimAge (β=0.30,p<.01) 有关.
- 加快的格林年龄预测了Aβ-40 (β=0.20,p<.001),Aβ-42 (β=0.18,p<.001) 和互白素-6 (β=0.18,p<.01) 的随后增加.
- 时间1的高级GrimAge,NFL和GFAP预测了时间2的更差的认知表现.
结论:
- 先进的GrimAge是未来神经病理学,炎症和认知衰退的重要预测因素.
- GrimAge介绍了精神病并发症和神经病理学之间的联系,提供了对神经退行途径的洞察.
- GrimAge对于理解认知衰老和识别患神经退行症高风险的个体具有临床意义.
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