身体活动和生活压力与多发性硬化症患者的疾病侵入性有关
Elizabeth S Gromisch1, Lindsay O Neto2, Heather M DelMastro2
1Mandell Center for Multiple Sclerosis, Mount Sinai Rehabilitation Hospital, Trinity Health Of New England, Hartford, CT; Department of Rehabilitative Medicine, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT; Department of Medical Sciences, Frank H. Netter MD School of Medicine at Quinnipiac University, North Haven, CT; Department of Neurology, University of Connecticut School of Medicine, Farmington, CT.
管理生活压力和增加体力活动可以减少多发性硬化症 (MS) 的疾病侵入性. 身体活动也间接影响MS残疾,改善生活质量.
科学领域:
- 神经学 神经学
- 生活方式 医学 医疗
- 生活质量研究 研究 生命质量研究
背景情况:
- 多发性硬化症 (MS) 显著影响患者的生活,疾病的侵入性影响日常功能.
- 识别可修改的生活方式因素对于管理多发性硬化症症状和改善患者的治疗结果至关重要.
研究的目的:
- 研究MS患者特定的生活方式行为与疾病侵入性之间的关系.
- 确定哪些可修改的行为,如饮食,体育活动和压力管理,影响MS的感知侵入性.
主要方法:
- 研究人员对154名患有多发性硬化症的成年人进行了队列研究.
- 参与者填写了在线问卷,评估疾病侵入性,生活方式行为 (饮食,体育活动,酒精,吸烟,生活压力) 和自我报告的体重指数.
- 对人口统计和临床因素 (如年龄,性别,疾病持续时间和残疾程度) 进行统计分析.
主要成果:
- 生活压力与疾病侵入性增加有显著的关联 (b=4.65,P<.001).
- 较高的体力活动水平与疾病侵入性降低有关 (b=-0.67,P=.009).
- 调解分析表明,身体活动通过对残疾的影响间接影响疾病侵入性.
结论:
- 生活压力和体力活动是影响MS疾病侵入性的关键可修改的生活方式行为.
- 身体活动通过残疾对疾病侵入性产生间接影响,这表明了干预的途径.
- 这些发现支持开发针对生活方式修改的行为干预措施,以提高MS患者的生活质量.
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