在西班牙人口中与真菌毒素暴露相关的因素
Nuria Dasí-Navarro1, Manuel Lozano2, Sabrina Llop3
1Laboratory of Food Chemistry and Toxicology, Faculty of Pharmacy, Universitat de València, Spain.
Environmental research
|November 15, 2023
概括
人体尿液生物监测显示,81%的女性广泛暴露于真菌毒素. 较高的水平与农村生活,较低的社会阶级以及酒,苏打水和果汁的消费有关.
科学领域:
- 环境健康 环境健康
- 毒理学 毒理学 毒理学
- 生物监测 生物监测
背景情况:
- 食品和料中菌毒素污染是全球健康问题.
- 人体尿液生物监测为评估菌根毒素暴露提供了食品分析的替代方案.
- 了解暴露模式和相关因素对于公共卫生至关重要.
研究的目的:
- 用尿样来描述人类对菌毒素的暴露.
- 调查与真菌毒素暴露相关的社会人口结构,生活方式和饮食因素.
- 量化特定的真菌毒素和查其他物质及其代谢物.
主要方法:
- 分析了西班牙INMA队列中540名妇女的尿样.
- 使用高性能液态染色学-四极飞行时间质谱法 (HPLC-Q-TOF-MS) 验证的多菌毒素方法的应用.
- 两变量和多变量回归模型用于评估与问卷数据的关联.
主要成果:
- 在81%的尿样中检测到毒素;151个样本的含量可以量化.
- 恩尼亚B (26%) 和恩尼亚B1 (7%) 是最频繁量化的真菌毒素.
- 较高的真菌毒素度与农村居住,较低的社会阶层以及酒,轻饮苏打水和果汁的消费相关.
结论:
- 在受研究的人群中观察到广泛的人类暴露于真菌毒素,特别是恩尼亚.
- 饮食习惯 (酒,苏打水,果汁,加工肉类) 和社会经济因素影响菌根毒素暴露水平.
- 需要进一步的研究来澄清食物来源和毒素暴露的环境联系.
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