长期暴露于臭氧和中年儿童的肺功能
Marnie F Hazlehurst1, Logan C Dearborn1, Allison R Sherris1
1Department of Environmental and Occupational Health Sciences, School of Public Health, University of Washington, Seattle, WA, USA.
Environmental research
|November 15, 2023
概括
这项研究没有发现臭氧 (O3) 暴露对儿童中年期肺功能 (FEV1和FVC) 的不良影响. 需要进一步的研究,以了解污染水平较高的地区的潜在影响.
科学领域:
- 环境健康 环境健康
- 儿科肺病学 儿科肺病学
- 流行病学 流行病学
背景情况:
- 已知暴露于臭氧 (O3) 在动物模型中会破坏肺部发育.
- 流行病学研究表明,长期暴露于O3和儿童肺功能受损之间存在潜在联系,但研究结果不一致.
- 很少有研究研究了儿科人口中的易受伤害的子组,以了解O3暴露的影响.
研究的目的:
- 调查长期环境臭氧 (O3) 暴露与8-9岁儿童肺功能之间的关联.
- 为了探索孩子的性别,支气管炎史和过敏敏感化的潜在效果修饰.
主要方法:
- 利用了来自CANDLE研究的数据,怀孕队列,包括在8-9岁时进行螺旋计的儿童和从出生起的住院病史.
- 基于住宅历史的经过验证的时空模型使用估计一生平均环境O3暴露.
- 分析了O3暴露与肺功能 (FEV1,FVC z-score) 之间的关联,使用线性回归,调整相关因素.
主要成果:
- 这项研究包括648名儿童,从出生到8岁,他们的平均O3暴露量很小 (26.6ppb).
- 长期暴露于O3和FEV1或FVC之间没有发现显著的不良关联.
- 没有发现儿童性别,婴儿支气管炎病史或过敏敏感性改变效果的证据.
结论:
- 在这种经历低O3度的队列中,在早期O3暴露和中年儿童肺功能之间没有观察到不良关联.
- 研究结果表明,在较低的暴露水平下,O3可能不会显著影响儿童的肺功能发展.
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