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这是一种肌痛! 它来自哪里?

Hsun-Hua Lee¹, Chih-Cheng Chen²

¹Department of Neurology, Taipei Medical University Hospital, Taipei Medical University, Taipei 11031, Taiwan; Department of Neurology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan; Dizziness and Balance Disorder Center, Taipei Medical University Hospital, Taipei Medical University, Taipei City, 11031, Taiwan; Department of Neurology, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan; Dizziness and Balance Disorder Center, Shuang Ho Hospital, Taipei Medical University, New Taipei City 23561, Taiwan.

Acta neurologica Taiwanica

|November 15, 2023

概括

肌肉疼痛,或肌痛,影响大多数人. 这项研究探讨了肌肉神经中的酸信号和氧化应激如何导致慢性疼痛,这可能导致新的纤维肌痛治疗方法.

科学领域:

神经科学是一个神经科学.
疼痛研究疼痛研究
分子生物学分子生物学

背景情况:

肌痛或肌肉疼痛是一种普遍的症状,影响60-85%的人口,通常与纤维肌痛等疾病有关.
目前对慢性肌痛的理解是有限的,对于难以治疗的病例缺乏有效的治疗方法.
组织酸化是已知的肌肉疼痛的贡献者,激活 nociceptors 中的质子感应离子通道.

研究的目的:

为了研究酸信号在肌肉 afferents的整合.
阐明慢性和难以治疗的肌肉疼痛背后的机制,特别是在纤维肌痛模型中.
探索氧化应激在激活质子感应离子通道和诱导疼痛中的作用.

主要方法:

使用了纤维肌痛的小鼠模型.
研究了肌肉 afferents 的酸信号通路.
研究了质子感应离子通道和氧化应激在疼痛诱导中的作用.

主要成果:

肌肉 afferents中的酸信号可以是亲nociceptive和反nociceptive,一个现象称为"sngception".
质子感应离子通道和受体在各种体感神经元子群体中表达.
氧化应激被确定为激活质子感应离子通道的因素,在小鼠中触发纤维肌痛类似的疼痛.

结论:

了解肌肉 afferents中的酸信号对于开发肌痛治疗的新治疗策略至关重要.
准质子感应离子通道和解决氧化应激可能为治疗慢性肌肉疼痛疾病 (如纤维肌痛) 提供新的途径.

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