抗结核疗法 (ATT) 诱导的血小板缺血:一个系统性审查
A Kaur1, R K Bhandari1, R Rohilla2
1Department of Pharmacology, Post Graduate Institute of Medical Education and Research, Chandigarh, 160012, India.
The Indian journal of tuberculosis
|November 15, 2023
概括
抗结核疗法 (ATT) 可以导致严重的,危及生命的血小板缺血症,主要与利芬素有关. 及时识别和管理对于患者的康复至关重要.
科学领域:
- 药物监督 药物监督 药物监督
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
背景情况:
- 药物诱导的血小板缺血是一种已知的不良事件.
- 抗结核疗法 (ATT) 是一种不常见但重要的血小板缺血的原因.
- 本综述侧重于一线ATT药物诱导的血小板缺血症:异化,利芬素,皮拉津胺和乙醇.
研究的目的:
- 审查一线ATT药物诱导的血小板缺血的概况.
- 了解ATT诱导的血小板缺血的临床特征和结果.
主要方法:
- 系统审查案例报告,案例系列和写给编辑的信件.
- 从1970年到2021年在PubMed/MEDLINE,奥维德和EMBASE进行的文献搜索.
- 在研究选择和报告时遵循了PRISMA指南.
主要成果:
- 包括17个案例报告和7封给编辑的信件.
- 里芬素是最常见的血小板缺血的原因 (65%).
- 观察到血小板数中位数下降到20,000/mm3;大多数患者对症状治疗有反应.
结论:
- 由ATT诱导的血小板缺血可能是严重的,需要住院治疗.
- 早期临床意识和适当的管理策略至关重要.
- 本综述为管理ATT诱导的血小板缺血提供了全面的概述.
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