在患有高血压的老年患者中,强化血压控制对动脉硬的影响
Shuyuan Zhang1,2, Yixuan Zhong3, Shouling Wu4
1National Clinical Research Center of Cardiovascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing 100037, China.
Chinese medical journal
|November 15, 2023
概括
密集的血压控制显著减缓了老年人的动脉硬化. 这种方法还可以降低高血压患者,特别是70-80岁患者的心血管疾病 (CVD) 风险.
科学领域:
- 心脏病学 心脏病学
- 老年学是一门学科.
- 高血压研究 高血压研究
背景情况:
- 动脉硬化是衰老和高血压的标志,增加了心血管疾病 (CVD) 的风险.
- 密集降低血压对老年人动脉硬化的影响仍然不确定.
研究的目的:
- 为了评估密集的血压治疗对动脉硬度进展的影响.
- 评估密集治疗对老年高血压患者心血管疾病风险的影响.
主要方法:
- 老年高血压患者的血压干预策略 (STEP) 试验随机将8511名患者 (60-80岁) 随机分配到密集 (SBP <130 mmHg) 或标准 (SBP 130-150 mmHg) 治疗中.
- 动脉硬 (臂脉冲波速 - baPWV) 和心血管疾病结局在5339名患者的3年随访期间进行了评估.
主要成果:
- 强化治疗显著降低了动脉硬度的进展 (baPWV变化:61.5比98.4厘米/秒).
- 强化治疗时每年baPWV的增加较小 (23.1 vs 36.7 cm·s -1 ·年 -1).
- 强化治疗降低了心血管疾病风险,特别是在70-80岁或基线SBP<140 mmHg的患者中.
结论:
- 密集的血压控制 (SBP 110-130 mmHg) 有效地延迟了老年高血压患者的动脉硬化.
- 这种密集的策略降低了这一群体心血管疾病的风险.
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