病理和体积生物标志物变化与临床正常成年人的认知衰退的关联
Bernard J Hanseeuw1, Heidi I L Jacobs1, Aaron P Schultz1
1From the Department of Radiology (B.J.H., H.I.L.J., N.J.G., J.A.B., J.S.S., J.S., H.-S.Y., M.N., J.C.P., G.E.F., K.A.J.), Massachusetts General Hospital, the Gordon Center for Medical Imaging, Boston; Department of Neurology (B.J.H.), Cliniques Universitaires Saint-Luc, Brussels, Belgium; Faculty of Health, Medicine and Life Sciences (H.I.L.J.), School for Mental Health and Neuroscience, Alzheimer Centre Limburg, Maastricht University, the Netherlands; Department of Neurology (A.P.S., R.F.B., M.E.F., M.P., Y.T.Q., P.V., J.P.C., G.A.M., R.A., K.P., D.M.R., R.A.S., K.A.J.), Massachusetts General Hospital; Center for Alzheimer Research and Treatment (R.F.B., P.V., G.A.M., R.A., K.P., D.M.R., R.A.S., K.A.J.), Department of Neurology, Brigham and Women's Hospital, Harvard Medical School, Boston; Melbourne School of Psychological Sciences (R.F.B.), University of Melbourne, Australia; and Department of Psychiatry (J.G.), and Department of Biostatistics (B.C.H.), Massachusetts General Hospital, Harvard Medical School, Boston.
海马体积 (HV) 缩预测认知能力的下降,独立于阿尔茨海默病的生物标志物. 连续HV测量可能会揭示非AD病理,有助于老年人记忆障碍.
科学领域:
- 神经成像是一种神经成像.
- 认知神经科学 认知神经科学
- 老年学是指老年学的学科.
背景情况:
- 海马体积缩 (HV) 是已知的记忆障碍生物标志物,但对阿尔茨海默病 (AD) 缺乏特异性.
- 本研究探讨了HV缩在认知中的作用,并考虑了潜在的共同病理.
- 评估HV缩对认知衰退的独特贡献对于理解非AD贡献至关重要.
研究的目的:
- 在10年内评估β-粉样蛋白 (Aβ),tau,HV和认知之间的关联.
- 在对Aβ和tau进行调整后,确定HV缩对认知衰退的独立贡献.
- 调查HV措施在识别非AD病理方面的作用.
主要方法:
- 来自哈佛老年大脑研究的128名认知正常老年人的前性队列研究.哈佛老年大脑研究.
- 收集了HV的长度MRI,Aβ和tau的PET,以及认知评估 (临床前阿尔茨海默氏症认知复合物).
- 使用序列模型来评估生物标志物对认知衰退的贡献.
主要成果:
- 更快的HV缩与更快的认知衰退相关 (R2 = 0.28,p < 0.0001).
- HV缩独立预测认知能力下降,占超出Aβ和tau的差异的10%.
- 综合成像生物标志物变化解释了认知衰退变异的45%.
结论:
- 纵向海马缩与认知能力下降有关,不论Aβ或tau水平如何.
- HV缩可能表明影响认知的非AD病理 (例如,TDP-43,血管).
- 连续HV测量提供了对目前的AD生物标志物无法检测的非AD病理的洞察力.
相关概念视频
Alzheimer's Disease: Overview
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
Cognitive Development During Adulthood
Dementia
The progression of dementia is generally gradual....


