代谢相关的脂肪肝病和肉症增加了死亡率:一个真实世界的研究
Qianwen Zhao1,2, Yifan Yin3, Yunlei Deng4
1Department of Gastroenterology & Hepatology, West China Hospital, Sichuan University, Chengdu, Sichuan, 610041, China.
Nutrition & diabetes
|November 15, 2023
概括
与代谢功能障碍相关的脂肪肝病 (MAFLD) 结合肉症显著增加死亡风险和肝纤维化. 解决肌肉质量对于MAFLD患者至关重要.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 老年病的医生 老年病的医生
- 代谢疾病 代谢疾病
背景情况:
- 萨科佩尼亚与非酒精性脂肪性肝病 (NAFLD) 的不良结果有关.
- 代谢功能障碍相关的脂肪肝疾病 (MAFLD) 与肉症的进展尚不清楚.
- 需要关于MAFLD和肉病对死亡率和肝纤维化的影响的真实数据.
研究的目的:
- 调查MAFLD和/或肉病与死亡率之间的关系.
- 评估MAFLD和/或肉症与肝纤维化之间的关联.
- 澄清MAFLD和肉症对不良健康结果的综合影响.
主要方法:
- 利用了来自全国健康和营养检查调查的13692名参与者的数据.
- MAFLD的诊断标准包括肝肥胖症加上超重/肥胖,糖尿病或代谢失调.
- 萨科佩尼亚是由体重调整的骨肌肉质量定义的;死亡率连接到2019年12月.
主要成果:
- 在该队列中发现了MAFLD (30.73%) 和肉症 (19.42%的MAFLD).
- 无论是MAFLD还是sarcopenia,都独立地增加了所有原因的死亡风险.
- 麻症和MAFLD的结合增加了死亡率和严重肝纤维化的风险.
结论:
- 麻症在MAFLD患者中与较高的死亡率和相当大的肝纤维化有关.
- 通过新疗法准骨肌肉质量可能有利于MAFLD患者.
- 早期识别和治疗皮病对于改善MAFLD预后至关重要.
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