肌肉衰弱对心脏代谢疾病和骨质疏松症的因果影响
Xiaoqing Mou1, Bin He2, Muzi Zhang3
1Department of Radiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China.
Scientific reports
|November 15, 2023
概括
肌肉衰弱因果性地增加了冠状动脉疾病的风险,降低了心力衰竭的风险. 这项遗传研究还表明,肌肉疲软可能会降低骨矿物质密度,为预防疾病提供了新的见解.
科学领域:
- 遗传学 遗传学 是一个
- 心脏病学 心脏病学
- 内分泌学 在内分泌学.
背景情况:
- 肌肉衰弱与心脏代谢疾病或骨质疏松症之间的关系尚未完全理解.
- 调查因果关系对于有效的预防和治疗策略至关重要.
研究的目的:
- 探索肌肉衰弱在心脏代谢疾病和骨质疏松症风险中的因果关系,使用双样本门德尔随机化方法.
- 为了确定可能的遗传倾向,将肌肉软弱与这些疾病联系起来.
主要方法:
- 利用与肌肉衰弱相关的15个单核酸多态 (SNPs) 作为工具变量.
- 采用孟德尔随机化 (MR) 分析,包括逆方差加权 (IVW) 和加权中位数方法.
- 评估了导致肌肉衰弱的遗传责任与冠状动脉疾病,心力衰竭,心房动,2型糖尿病,骨质疏松症和骨折等结果之间的关联.
主要成果:
- 肌肉衰弱的遗传倾向与冠状动脉疾病的风险增加有关 (P=0.009).
- 肌肉疲软显示心力衰竭风险降低 (P=0.036) 和估计骨矿物质密度 (eBMD) 降低 (P=0.023).
- 在心房动,2型糖尿病或骨折方面没有发现显著的MR关联.
结论:
- 肌肉衰弱与冠状动脉疾病和心力衰竭的发生有因果关系.
- 研究结果表明,肌肉疲软在减少骨矿物质密度方面可能起因作用.
- 这项研究为预防和治疗心脏代谢疾病和骨质疏松症提供了宝贵的见解.
更多相关视频
09:40Phosphorus-31 Magnetic Resonance Spectroscopy: A Tool for Measuring In Vivo Mitochondrial Oxidative Phosphorylation Capacity in Human Skeletal Muscle
Published on: January 19, 2017
11.7K
12:59Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People
Published on: July 5, 2017
12.6K
相关概念视频
Disorders of the Skeletal Muscle
966
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
966
Bone Disorders
3.6K
Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
3.6K
Chemical Synapses
8.9K
Chemical synapses are specialized sites between two neurons or between a neuron and a non-neuronal cell like a muscle, glandular or sensory cell.
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
Because chemical synapses depend on the release of neurotransmitter molecules from synaptic vesicles to pass on their signal, there is an approximately one millisecond delay between when the axon potential reaches the presynaptic terminal and when the neurotransmitter leads to opening of postsynaptic ion channels. Additionally, this signaling is...
8.9K
Cross-bridge Cycle
117.6K
As muscle contracts, the overlap between the thin and thick filaments increases, decreasing the length of the sarcomere—the contractile unit of the muscle—using energy in the form of ATP. At the molecular level, this is a cyclic, multistep process that involves binding and hydrolysis of ATP, and movement of actin by myosin.
117.6K
Pathophysiology of Cardiac Performance
674
Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
674
Overview of Protein Metabolism
1.2K
Proteins are broken down into amino acids during digestion. Unlike fats and carbohydrates, which are stored for later use, proteins are not. Instead, amino acids are either used to produce ATP through oxidation or contribute to the creation of new proteins for the growth and repair of the body. Any surplus amino acids from the diet are converted into glucose or triglycerides rather than excreted.
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
Amino acids play various roles in the body once they are absorbed into cells. They are restructured...
1.2K
