为接受全源干细胞移植的患者提供主动肠道营养 - 实施和临床结果
Sarah Andersen1,2, Rebecca Fichera3, Merrilyn Banks4,3
1School of Human Movement and Nutrition Sciences, University of Queensland, St Lucia, QLD, 4072, Australia. s.andersen@uq.edu.au.
European journal of clinical nutrition
|November 15, 2023
概括
肠道营养 (EN) 可能有助于改善异构血造原生细胞移植 (HPCT) 后的结果. 对EN使用存在障碍,但实施营养方案可以提高患者护理和生存率.
科学领域:
- 血液学 血液学 血液学
- 移植医学 移植医学
- 临床营养学 临床营养学
背景情况:
- 在全基血造原生细胞移植 (HPCT) 后,营养支持至关重要.
- 在HPCT患者中,对肠道营养 (EN) 的耐受性可能会变化.
- 对EN使用的障碍和促进因素需要探索以优化患者护理.
研究的目的:
- 调查工作人员对EN使用后HPCT的看法,障碍和推动因素.
- 实施和评估HPCT患者的营养方案.
- 在HPCT接受者中比较EN和亲肠道营养 (PN) 之间的临床结果.
主要方法:
- 一种混合方法的方法,结合了员工调查和回顾性患者数据分析.
- 调查分发给医疗和护理人员,以确定障碍物和促进因素.
- 收集12个月的营养和临床结果.
主要成果:
- 关键障碍包括不确定的EN耐受性,鼻胃管放置方面的挑战以及不充分的培训.
- 与接受PN的患者相比,仅接受EN的患者在第100天的生存率更好,住院时间更短.
- 营养不良的患者更有可能接受PN,这个群体的结果更差.
结论:
- 与腹腔营养 (PN) 相比,肠道营养 (EN) 可能与HPCT患者的改善临床结果有关.
- 在HPCT后,EN应该被认为是第一线营养支持策略.
- 解决已识别的障碍对于成功实施EN至关重要.
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