分布式滞后效应和PM和活跃肺结核的脆弱群体在中国青岛
Wei Ni1,2, Qiuling Shi3
1State Key Laboratory of Ultrasound in Medicine and Engineering, College of Biomedical Engineering, Chongqing Medical University, Chongqing, China.
International journal of biometeorology
|November 16, 2023
概括
暴露于颗粒物 (PM) 与活性肺结核 (TB) 有关. PM2.5显著增加了结核病风险,特别是在年轻人和工人中,突出了对污染控制策略的需要.
科学领域:
- 环境健康 环境健康
- 流行病学 流行病学
- 呼吸系统医学 呼吸系统医学
背景情况:
- 暴露于颗粒物 (PM) 是一个全球性问题,可能会对呼吸系统产生影响.
- 微粒子和活性肺结核 (TB) 之间的特定暴露-时间-反应关系仍未得到充分研究.
- 识别弱势群体对于有针对性的公共卫生干预至关重要.
研究的目的:
- 研究颗粒物 (PM) 对活性肺结核 (TB) 的分布式滞后效应.
- 量化PM和结核病发病率之间的暴露时间响应关系.
- 确定易受PM诱导的结核病影响的人口和职业群体.
主要方法:
- 使用了通用增剂混合模型与分布式滞后非线性模型相结合.
- 分析了16486例已报告的活跃肺结核病例.
- 计算相对风险 (RR) 和累计RR,使用95%的置信区间 (CI) 来评估随时间推移的颗粒暴露影响.
主要成果:
- 每日PM2.5度增加10μg/m3与活性肺结核发病率增加有关,在66个滞后天达到峰值 (RR=1.0076).
- 累计PM2.5的RR为2.1940,这表明长期风险很大.
- 在73-117个滞后日,PM10显示出正相关性,但累积RR并不显著.
- 在各种年龄组 (0-18,19-64岁),性别和职业 (工人,学生) 中观察到对PM2.5的脆弱性.
结论:
- 颗粒物,特别是PM2.5,与活性肺结核病有显著的关联.
- 该研究确定了特定的滞后期和PM暴露对结核病风险的累积影响.
- 调查结果强调了减少颗粒物污染的重要性,以减轻结核病发病率,特别是在确定的脆弱人群中.
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