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不同细胞死亡模式对肺腺癌的预后和免疫的影响

Yang Zhou1, Weitong Gao1, Yu Xu2

  • 1Department of Medical Oncology, Harbin Medical University Cancer Hospital, 150081, Harbin, China.

NPJ precision oncology
|November 16, 2023
PubMed
概括

肺腺癌 (LUAD) 的预后可以使用新型细胞死亡指数 (CDI) 签名来预测. 这个签名识别了可能从免疫治疗中受益的患者,改善了LUAD患者的诊断准确性和结果.

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
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