生物材料设备的受控膨胀,用于改进的防聚合物涂层
Alexander H Jesmer1, April S T Marple1, Ryan G Wylie2,3
1Department of Chemistry and Chemical Biology, McMaster University, Hamilton, ON, L8S 4M1, Canada.
Scientific reports
|November 16, 2023
概括
一种新的Graft then shrink (GtS) 方法改善了医疗弹性体上的防涂层. 这种技术显著增强了聚合物接种,减少了植入物和导管等器件上的细胞粘附.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 表面工程是什么?表面工程是什么?
背景情况:
- 非特定的细胞表面相互作用会导致可植入弹性体装置的故障.
- 水友性聚合物涂层增强抗性质,高聚合物密度提高性能.
- 现有的移植到方法更简单,但与移植到技术相比,聚合物密度较低.
研究的目的:
- 开发一种改进的移植到方法,用于在弹性体上制造密集的,防的聚合物涂层.
- 为了增强Graft然后收缩 (GtS) 技术,用于在上的聚乙烯基甲基酸 (pOEGMA) 涂层.
主要方法:
- 开发了移植然后收缩 (GtS) 方法,涉及在聚合物移植之前膨胀弹性质材料.
- 使用GtS将pOEGMA涂层应用到上,并根据膨胀的程度而变化.
- 将GtS涂层与非膨胀对照和收缩然后移植 (StG) 方法进行了比较.
主要成果:
- 与非膨胀的对照组相比,GTS增加了pOEGMA在上移植的聚合物含量约13倍.
- 的膨胀程度直接影响了接种的聚合物的数量.
- GtS涂层减少了细菌和哺乳动物细胞粘附率,分别为75%和91%.
结论:
- GtS方法提供了一种简单而有效的方法,可以在可膨胀弹性体上创建高效的抗涂层.
- GtS显著提高了基于的医疗器械的聚合物接种和污染抵抗力.
- 这种技术有望提高各种可植入装置的寿命和性能.
相关概念视频
Plasticizers
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Superplasticizers
Superplasticizers are advanced admixtures that enhance the workability of concrete by lowering the water content without compromising the strength of the material. These substances are highly effective water reducers, improving concrete flow, making it easier to work with, and enabling concrete to reach inaccessible areas or densely reinforced sections without mechanical vibration. The key components in superplasticizers are either sulfonated melamine or naphthalene formaldehyde condensates,...
Bioreactor Controls-I
Maintaining optimal conditions within fermenters is essential for maximizing microbial productivity and ensuring process efficiency. This lesson focuses on key parameters—temperature, foam, pH, carbon dioxide, oxygen, and pressure—and their precise measurement and control strategies in fermentation systems.Temperature ControlTemperature regulation is critical due to the exothermic nature of many fermentation processes. In small laboratory fermenters, temperature is commonly monitored using...
Bioreactor Controls-II
In aerobic fermentations, oxygen is vital for microbial growth and metabolite production. Since air comprises only about 20% oxygen and the gas is poorly soluble in water—just 9 ppm at 20°C—supplying sufficient oxygen becomes a critical challenge, especially in high-demand processes like yeast growth or citric acid production. Even a fully saturated broth may offer only a few seconds of oxygen availability.To address this, sterile or scrubbed air is introduced into the fermentor via a sparger...
Bioreactor Controls-III
Strain improvement is a foundational strategy in industrial microbiology aimed at maximizing microbial productivity, particularly because natural isolates typically yield commercially valuable products in very low concentrations. Although optimizing the culture medium and environmental conditions can improve yields, these adjustments are inherently limited by the organism’s genetic potential. As a result, the focus shifts toward genetic modifications to enhance biosynthetic capacity. The...
Bioplastics
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...


