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功能和移植在腹综合征:一个范围审查审查
Adree Khondker1,2,3, Ihtisham Ahmad1, Kellie Kim1
1Temerty Faculty of Medicine, University of Toronto, Toronto, ON, Canada.
Pediatric nephrology (Berlin, Germany)
|November 16, 2023
概括
患有腹综合征 (PBS) 的儿童面临严重的脏问题,包括慢性脏病 (CKD) 和脏替代疗法 (KRT). 本次审查强调了报告的变化,并呼吁进行标准化数据收集,以获得更好的患者结果.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 儿科泌尿外科 儿科泌尿外科
- 医学研究综合 医学研究综合
背景情况:
- 腹综合征 (PBS) 显著增加了儿童功能障碍和替代疗法 (KRT) 的风险.
- 现有的研究主要集中在手术和生存结果上,对脏特异性结果的合成有限.
- 在所有年龄组中缺乏对PBS脏结果的全面了解.
研究的目的:
- 进行对腹综合征患者结局现有文献的范围审查.
- 确定知识差距,并评估PBS中脏结果的报告标准.
- 综合目前关于功能,慢性病 (CKD) 和PBS中的KRT的证据.
主要方法:
- 采用了一种系统的范围审查方法.
- 在EMBASE,MEDLINE和Scopus中搜索相关的同行评审文献.
- 包括报告广泛结局的研究,包括功能,CKD和KRT,并进行了定性合成.
主要成果:
- 涉及441名患者的25项研究报告了功能不全,CKD患病率在8%至66%之间.
- 15项研究详细介绍了314名患者的置换疗法 (KRT),KRT开始于4至21岁之间.
- 在1.3至27年的随访期内,移植移植的存活率差异很大,从22%到87%不等.
结论:
- 在报告PBS结局时存在显著的异质性,阻碍了有意义的合成.
- 未来的研究非常需要采用PBS中功能衰竭的混因子和病因因素的标准化报告.
- 改进数据收集标准对于促进PBS中脏并发症的理解和管理至关重要.
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