口腔疾病的全身代谢特征
A Salminen1, A M Määttä1, P Mäntylä2,3
1Oral and Maxillofacial diseases, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Journal of dental research
|November 16, 2023
概括
牙周炎等口腔疾病与改变的血液代谢物有关,这表明与全身炎症和心脏代谢障碍有关. 解决口腔健康问题可能有助于管理这些慢性疾病.
科学领域:
- 生物化学 生物化学
- 口腔医学是指口腔医学.
- 代谢学 代谢学 代谢学
背景情况:
- 口腔疾病对全身代谢影响的研究不足.
- 缺乏关于口腔健康和全身代谢物的前性数据.
研究的目的:
- 调查当前/过去口腔传染性/炎症性疾病和循环中的代谢物之间的关联.
- 探索口腔健康对未来代谢概况的预测价值.
主要方法:
- 利用了来自Health-2000 (n=6,229) 和Parogene (n=452) 队列的数据.
- 使用核磁共振光谱测量了157种血清代谢物.
- 采用线性回归模型,调整了混因子.
主要成果:
- 与改变的低密度脂蛋白和脂肪酸特征相关的.
- 牙周病与脱脂症,氨基酸变化和炎症标志物有关.
- 口腔疾病与代谢特征相关,表明全身炎症.
结论:
- 口腔感染/炎症状况与不同的全身代谢概况有关.
- 特别是牙周炎,与与炎症相关的代谢物有很强的联系.
- 口腔健康可能是慢性全身炎症和心脏代谢疾病的可修改风险因素.
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