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免疫疗法和肺细胞病理学:概述和可能性

Maria D Lozano^1,2,3, Allan Argueta¹, Carlos de Andrea^1,2,3,4

¹Department of Pathology, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain.

Cytopathology : official journal of the British Society for Clinical Cytology

|November 16, 2023

概括

免疫疗法在癌症治疗方面表现有前途,PD-L1测试对评估至关重要. 这篇评论探讨了细胞病理学.

科学领域:

瘤学和病理学
癌症免疫治疗研究癌症免疫治疗研究

背景情况:

免疫疗法已经成为一种重要的癌症治疗方式.
免疫组织化学 (IHC) 是编程死亡连接体1 (PD-L1) 和编程死亡1 (PD1) 评估的标准.
PD-L1测定适用于甲固定嵌 (FFPE) 组织和细胞样本,但涂抹的验证正在进行中.

研究的目的:

通过免疫细胞化学 (ICC) 审查细胞病理学在分析PD-L1表达中的作用.
在癌症免疫治疗的背景下探索细胞病理学的未来方向.
突出在细胞学样本中对PD-L1解释的先进成像和算法的潜力.

主要方法:

在细胞学样本中对PD-L1测试现有文献的审查.
讨论用于PD-L1评估的免疫组织化学 (IHC) 和免疫细胞化学 (ICC) 技术.
在最小侵入性细胞学样本上进行多重免疫光 (mIF) 分析的探索.

主要成果:

虽然IHC已经确立,但在细胞学涂抹上应用PD-L1测定需要进一步验证.
数字成像和算法为在细胞学样本中改进PD-L1的解释提供了潜力.
在细胞学样本上的多重复合免疫光 (mIF) 是研究非小细胞肺癌 (NSCLC) 瘤免疫微环境的一个有希望的方法.

结论:

细胞病理学在评估免疫疗法的生物标志物方面发挥着越来越重要的作用.
需要进一步的研究和验证,以优化对细胞学样本的PD-L1测试.
像mIF这样的先进技术对NSCLC的综合免疫分析具有前途.

关键词:

生物标志物生物标志物细胞块的细胞块.细胞科学细胞学数字病理学数字病理学精细的针吸入精细的针.肺肺肺肺肺肺肺肺肺非小细胞肺癌 (NSCLC) 是一种非小细胞肺癌.编程死亡连接体1 (PD-L1) 编程死亡连接体涂抹涂抹的涂抹是什么意思

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