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多胎妊娠史和长期母亲死亡率的历史

Susanna D Mitro^1,2, Rajeshwari Sundaram¹, Yan Qiao¹

¹Division of Population Health Research, Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, Maryland, USA.

Paediatric and perinatal epidemiology

|November 16, 2023

概括

多胎妊娠史与总体孕产妇死亡率无关,但在长期研究中显示,早产死亡风险降低. 这一发现对于了解长期母亲健康结果至关重要.

科学领域:

生殖健康生殖健康
流行病学流行病学
孕产妇死亡率研究研究

背景情况:

多胎妊娠增加了孕前和早产的风险,可能会增加长期的母亲心血管风险.
了解多胎妊娠对长期死亡的影响对于母亲健康至关重要.
以前的研究表明,怀孕并发症和以后的心血管问题之间存在联系.

研究的目的:

调查自发受孕多胎妊娠与长期孕产妇死亡率之间的关联.
为了比较所有原因和心血管死亡率在妇女和没有多胎妊娠的历史.
评估与多胎妊娠史相关的过早死亡风险.

主要方法:

利用了合作周产期项目 (1959-1966) 中44,174名母亲的数据.
使用国家死亡指数和社会保障死亡主文件,追踪生命状况至2016年.
使用了根据人口统计,吸烟和先前存在的条件调整的Cox比例危险模型.

主要成果:

在调整后的研究期间,多胎妊娠史与全因或心血管死亡率的增加无关.
具有多胎妊娠史的妇女在统计学上具有显著的11%较低的任何原因过早死亡风险.
具有多胎妊娠史的参与者年龄较大,更有可能患有先前存在的疾病或吸烟.

结论:

长期随访表明,与多胎妊娠史相关的全因死亡率没有增加.
有多胎妊娠史可能与早逝风险降低有关.
进一步的研究可以探索观察到的减少过早死亡率背后的机制.

关键词:

孕产妇死亡率孕产妇死亡率多重怀孕是一个多重怀孕.过早死亡率过早死亡率

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