在帕金森病中,血压变化与认知衰退之间的关联
Yi Xiao1, Tianmi Yang1, Lingyu Zhang2
1Department of Neurology, Rare Disease Center, Laboratory of Neurodegenerative Disorders, National Clinical Research Center for Geriatric, West China Hospital of Sichuan University, Chengdu, Sichuan, China.
Brain and behavior
|November 16, 2023
概括
高血压变化 (BPV) 与轻度认知障碍的早期帕金森病 (PD) 患者的认知下降速度更快有关. 这一发现凸显了BPV作为PD认知恶化的潜在预测因素.
科学领域:
- 神经学 神经学
- 心脏病学 心脏病学
- 老年学是一门学科.
背景情况:
- 高访问到访问血压变化 (BPV) 是已知的认知衰退的风险因素在老年人.
- 帕金森病 (PD) 经常与认知障碍有关,而BPV在这种情况下的作用尚不清楚.
研究的目的:
- 研究一次次访问的BPV对早期帕金森病 (PD) 患者的认知功能的影响.
- 确定BPV是否预测PD患者的认知衰退,区分具有轻度认知障碍和没有轻度认知障碍的人.
主要方法:
- 从帕金森病进展标志物倡议研究中对297名早期PD患者的前性队列进行了回顾性分析.
- 在第一年使用独立于缩血压平均值 (VIM) 的变化评估BPV.
- 使用蒙特利尔认知评估 (MoCA) 评估全球认知,并使用贝叶斯线性增长模型分析纵向生物标志物.
主要成果:
- 在第一年内,较高的缩性VIM与轻度认知障碍 (PD-MCI) 的PD患者的认知能力下降 (MoCA得分下降) 的更高率有关.
- 在BPV和评估的大脑脊髓液或血清生物标志物之间没有发现显著的关联.
- 系统性VIM与认知衰退之间的关联即使考虑到平均血压和其他血液动力学因素,仍然很显著.
结论:
- 较高的缩血压变化是轻度认知障碍早期PD患者加速认知衰退的预测因素.
- BPV可以作为一种有价值的临床标志物,用于识别患有认知恶化风险较高的PD患者.
- 需要进一步的研究来探索将BPV与PD认知衰退联系在一起的机制.
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