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表达衰老相关特征的循环单细胞在患有严重疾病的COVID-19患者中得到了丰富

Y Lin¹, D F Postma², L S Steeneken¹

¹European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen (UMCG), University of Groningen (RUG), Groningen, Netherlands.

|November 16, 2023

概括

血液中的细胞衰老标记可以预测SARS-CoV-2感染和COVID-19的严重程度. 单细胞表现出增加的衰老,这表明在炎症和疾病进展中发挥了作用.

科学领域:

免疫学免疫学免疫学
病毒学病毒学
老年学是指老年学的学科.

背景情况:

由于对SARS-CoV-2病原体的不完全理解,需要准确的生物标志物来预测COVID-19的严重程度.
细胞衰老及其亲炎性表型与COVID-19有关,但标记物主要在下呼吸道中发现.

研究的目的:

调查COVID-19患者可访问的生物样本中老化相关标记物的存在和预测价值.
为了确定血液中的细胞衰老是否可以作为SARS-CoV-2感染和疾病严重程度的生物标志物.

主要方法:

从COVID-19患者和对照组的全血,血和PBMC中测量了与衰老相关的特征.
使用了大量的转录组,向蛋白组和单细胞RNA测序试验.

主要成果:

衰老标志物,包括衰老相关的分泌表型 (SASP),预测SARS-CoV-2感染.
在COVID-19患者的单细胞中丰富了衰老特征,与疾病严重程度相关.
单细胞似乎因SARS-CoV-2感染而过早导致衰老.

结论:

血液中的细胞衰老,特别是在单细胞中,可以作为COVID-19的预测生物标志物.
由于SARS-CoV-2引起的单细胞衰老可能会导致炎症反应和疾病恶化.
这些发现为COVID-19及其后果的新型诊断和预后工具提供了潜力.

关键词:

在 COVID-19 疫情中,这就是SARS-CoV-2病毒.在 SASP 找 SASP 年龄化的衰老.细胞衰老细胞衰老单细胞 (Monocytes) 是一种单细胞.

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