在自愿轮子运行过程中,皮层微质动力学得到保存
Alexandra O Strohm1, Thomas N O'Connor2,3, Sadie Oldfield4
1Department of Environmental Medicine, University of Rochester Medical Center, Rochester, New York, United States.
Journal of applied physiology (Bethesda, Md. : 1985)
|November 16, 2023
概括
身体炼,如自愿的轮子运行,不会显著改变微质动力学或健康成年小鼠受伤的反应. 运动可能通过直接改变小质细胞以外的其他机制对大脑有好处.
科学领域:
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
- 运动生理学 运动生理学
背景情况:
- 微质细胞是中枢神经系统的主要免疫细胞,在大脑健康和疾病中起着至关重要的作用.
- 身体炼对微质行为和活体功能的影响仍然不完全理解.
- 了解运动如何影响小质细胞对于探索其治疗神经疾病的治疗潜力至关重要.
研究的目的:
- 为了研究慢性自愿轮流对微质动力学,形态学和对伤害的反应 in vivo 的影响.
- 为了确定体育炼是否会改变健康成年小鼠微质的表型.
- 在疾病模型中建立未来对运动和微质细胞研究的基础.
主要方法:
- 利用慢性体内成像技术,随着时间的推移观察小质在参与自愿轮子运行 (VWR) 的小鼠中.
- 在运动期间评估微质动态,包括运动,形态和过程运动性.
- 在运动小鼠和静止小鼠中对激光除损伤的评估微质反应.
主要成果:
- 微质动力学,形态学和过程运动性在慢性自愿轮子运行期间在健康小鼠中保持稳定.
- 与静止对照对照相比,运动小鼠对激光切除损伤表现出类似的微质反应.
- 这些发现表明,VWR在健康的成年小鼠中不会大大改变皮质微质表型.
结论:
- 在健康小鼠中,一个月以上运行的自愿轮并没有诱导微质动力学或损伤反应的显著变化.
- 运动对大脑的有益影响可能通过独立于直接微质变化的途径进行介导.
- 进一步的研究是有必要的,以探索运动诱导的微质变化在疾病和伤害背景.
相关概念视频
Power Expended by a Constant Force
The relationship between work done and the time taken to do it can be explained using the concept of power. For example, several sprinters in a race may have the same velocity when they reach the finish line, therefore doing the same amount of work, but the winner does it in the least amount of time. Thus, power is defined as the rate of doing work. Since work can vary as a function of time, the average power is defined as the work done during a time interval, divided by the time interval.
Conservation of Angular Momentum
A system's total angular momentum remains constant if the net external torque acting on the system is zero. Considering a system that consists of n tiny particles, the angular momentum of any tiny particle may change, but the system's total angular momentum would remain constant. The principle of conservation of angular momentum only considers the net external torque acting on the system. While there are internal forces exerted by different particles within the system that also produce internal...
Rolling Resistance
When a solid cylinder rolls steadily on a rigid surface, the normal force applied by the surface on the cylinder is perpendicular to the tangent at the contact point. However, since no materials are entirely rigid, the surface's reaction to the cylinder involves a range of normal pressures.
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
For instance, imagine a hard cylinder rolling on a comparatively soft surface. The cylinder's weight compresses the surface beneath it. As the cylinder moves, the material in front of it slows down due to...
Rolling Resistance: Problem Solving
Rolling resistance, also known as rolling friction, is the force that resists the motion of a rolling object, such as a wheel, tire, or ball, when it moves over a surface. It is caused by the deformation of the object and the surface in contact with each other, as well as other factors like internal friction, hysteresis, and energy losses within the materials. Rolling resistance opposes the object's motion, requiring additional energy to overcome it and maintain movement. In practical...
Conservation of Mechanical Energy
The mechanical energy E of a system is the sum of its potential energy U and the kinetic energy K of the objects within it. What happens to this mechanical energy when only conservative forces cause energy transfers within the system—that is, when frictional and drag forces do not act on the objects in the system? Also assume that the system is isolated from its environment; in other words no external force from an object outside the system causes energy changes inside the system.
When a...
When a...
Rolling Without Slipping
People have observed the rolling motion without slipping ever since the invention of the wheel. For example, one can look at the interaction between a car's tires and the surface of the road. If the driver presses the accelerator to the floor so that the tires spin without the car moving forward, there must be kinetic friction between the wheels and the road's surface. If the driver slowly presses the accelerator, causing the car to move forward, the tires roll without slipping. It is essential...


