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阐明与cuproptosis相关的基因SLC31A1在癌症癌症中的诊断和预后值

Jiaoping Mi^1,2, Juncong Luo³, Huanwen Zeng³

¹Department of Otorhinolaryngology Head and Neck Surgery, The First Affiliated Hospital, Sun Yat-sen University Guangzhou 510080, Guangdong, PR China.

American journal of translational research

|November 16, 2023

概括

作为cuproptosis的关键调节剂,SLC31A1在乳腺癌 (BRCA),子宫状细胞癌 (CESC),头状细胞癌 (HNSC) 和食道癌 (ESCA) 中过度表达. 这种过度表达与更差的生存率相关,并表明SLC31A1是潜在的诊断生物标志物和治疗点.

科学领域:

在瘤学瘤学.
细胞死亡机制细胞死亡机制
分子生物学分子生物学

背景情况:

铜,一种依赖铜的细胞死亡,是癌症治疗的新领域.
SLC31A1 是一个关键的载体,参与细胞的铜吸收和亡调节.
识别新的生物标志物和治疗点对于改善癌症治疗结果至关重要.

研究的目的:

研究SLC31A1在各种癌症类型中的临床意义.
评估SLC31A1作为潜在的诊断生物标志物和预后指标.
探索SLC31A1作为抗癌策略的治疗点.

主要方法:

使用TIMER2.0.1进行SLC31A1表达的泛癌分析.
通过KM绘图器进行生存分析,并使用UALCAN/HPA进行表达验证.
使用cBioPortal,ULACAN,OncoDB和TIMER2.0.0进行甲基化,突变和免疫透分析.
在临床样本中进行基因丰富分析 (Metascape) 和RT-qPCR验证.

主要成果:

在BRCA,CESC,HNSC和ESCA中,SLC31A1显著上调并与较差的整体存活率相关.
低甲基化被确定为这些癌症中SLC31A1过度表达的主要驱动因素.
SLC31A1的表达与免疫细胞透 (CD8+ T细胞,CD4+ T细胞,巨细胞) 相相关,并揭示了潜在的分子通路.
通过RT-qPCR检测证实SLC31A1的诊断潜力具有较高的AUC值.

结论:

在BRCA,CESC,HNSC和ESCA中,SLC31A1的调节升高,与更差的预后相关.
SLC31A1显示出作为诊断生物标志物和这些癌症的新治疗点的潜力.
了解SLC31A1在cuproptosis和瘤微环境中的作用为癌症治疗提供了新的途径.

关键词:

在SLC31A1A1中.生物标志物生物标志物癌分析分析癌分析

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