甲福明可以改善胰岛素耐药性,甲状腺结节和甲状腺功能.
Shuhong Ji1, Ruixin Gao2, Qinghua Gao3
1Department of Endocrinology, Dezhou Hospital of Traditional Chinese Medicine Dezhou, Shandong, China.
American journal of translational research
|November 16, 2023
概括
在IR患者中,甲福明显著改善了胰岛素抵抗 (IR) 和甲状腺结节 (TNs). 甲福明治疗还降低了氧化应激,调节了甲状腺刺激激素 (TSH) 水平,证明了高安全性.
科学领域:
- 内分泌学 在内分泌学.
- 代谢障碍 代谢障碍 代谢障碍
- 甲状腺学 甲状腺学
背景情况:
- 胰岛素抵抗 (IR) 是一种与各种健康问题相关的代谢状况.
- 甲状腺结节 (TNs) 很常见,并且它们的管理可能是复杂的,特别是在患有并发性IR的患者中.
- 了解IR,甲状腺功能和TN之间的相互作用对于有效的患者护理至关重要.
研究的目的:
- 为了研究甲型胺对胰岛素抵抗 (IR) 的影响.
- 为了评估甲福明对甲状腺结节 (TNs) 和甲状腺功能在IR患者的影响.
- 评估甲福明作为辅助治疗的安全性和有效性.
主要方法:
- 对128名具有IR的TN患者进行了回顾性分析.
- 对照组 (生活方式干预) 和研究组 (生活方式干预+甲胺) 的比较.
- 在治疗1年之前和之后评估体重,红外线标记,甲状腺功能,TN大小和氧化应激.
主要成果:
- 甲福明显著降低了禁食血葡萄糖 (FPG),2小时食后葡萄糖 (2hPG),糖化血红蛋白 (HbA1c),禁食胰岛素 (FINS) 和HOMA-IR.
- 研究小组的甲状腺刺激激素 (TSH) 水平显著改善,减少了甲 (MDA),TN直径和体积减少.
- 虽然不良反应在甲双组中更频繁,但甲双和自由甲状腺素 (FT4) 被确定为TSH的保护因素.
结论:
- 甲福明有效地改善了TN患者的IR和氧化应激IR.
- 甲胺治疗导致TSH水平的调节和TN大小的减少.
- 甲胺显示出高安全性和有效性,甲胺和FT4是积极预后的关键因素.
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