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奶酪摄入与妊娠高血压和糖尿病的因果关系关系来自孟德尔随机化研究的结果
Tao Zhong1, Yu-Qing Huang2, Gui-Ming Wang3
1Department of Cardiology, The First Hospital of Nanchang, Nanchang 330008, Jiangxi Province, China.
消费奶酪可能会降低妊娠高血压和妊娠糖尿病的风险. 这项门德尔随机化研究表明,吃奶酪和改善妊娠结果之间存在有益的因果关系.
科学领域:
- 产科和妇科 产科和妇科
- 营养科学 营养科学
- 遗传流行病学遗传流行病学
背景情况:
- 观察性研究对奶酪摄入量与怀孕并发症之间的因果关系产生了不确定的结果.
- 孕期高血压和孕期糖尿病对母亲和胎儿的健康构成重大风险.
研究的目的:
- 调查奶酪消费与妊娠高血压和妊娠糖尿病发展之间的潜在因果关系.
- 利用遗传数据对这种关联进行可靠的评估.
主要方法:
- 采用了两个样本的门德尔随机化 (MR) 研究设计.
- 奶酪摄入量 (暴露) 和结果 (妊娠高血压,妊娠糖尿病) 的遗传数据来自IEU OpenGWAS数据库.
- 逆方差加权和灵敏度分析 (MR-Egger,加权中位数,加权模式,留出一个) 用于评估因果关系和排除偏差.
主要成果:
- 增加奶酪摄入量与妊娠高血压风险降低有关 (OR = 0.60,P < 0.001).
- 增加奶酪摄入量也与妊娠糖尿病风险降低有关 (OR = 0.41,P < 0.001).
- 敏感性分析表明,对于妊娠高血压,没有显著的异质性或水平性,尽管在妊娠糖尿病中注意到了一些异质性.
结论:
- 门德尔的随机化分析表明,奶酪摄入量与妊娠高血压和妊娠糖尿病之间存在反向关联.
- 研究结果表明,奶酪消费可能在预防这些与怀孕有关的疾病方面起到有益的作用.
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