相关实验视频

Updated: Jul 11, 2025

Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes
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Chemoselective Preparation of 1-Iodoalkynes, 1,2-Diiodoalkenes, and 1,1,2-Triiodoalkenes Based on the Oxidative Iodination of Terminal Alkynes

Published on: September 12, 2018

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生物活性分子的C-H放射化通过顺序化/铜介导交叉合

Mami Horikawa1, Stephen T Joy1, Liam S Sharninghausen1

  • 1Department of Chemistry, University of Michigan 930 North University Avenue Ann Arbor Michigan 48109 USA amapp@umich.edu mssanfor@umich.edu.

Chemical science
|November 16, 2023
PubMed
概括

这项研究引入了一种新的C-H放射化方法,用于用碳-11标记 (异质) 芳香化合物. 反应选择性地功能化富含电子的基质,包括,为放射化学提供了有价值的工具.

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Synthesis of Hypervalent Iodonium Alkynyl Triflates for the Application of Generating Cyanocarbenes12:27

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Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
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Cycloadditions are one of the most valuable and effective synthesis routes to form cyclic compounds. These are concerted pericyclic reactions between two unsaturated compounds resulting in a cyclic product with two new σ bonds formed at the expense of π bonds. The [4 + 2] cycloaddition, known as the Diels–Alder reaction, is the most common. The other example is a [2 + 2] cycloaddition.
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Phase II biotransformations are detoxification mechanisms that conjugate xenobiotics with endogenous substances, neutralizing their toxicity.
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