慢性病与大脑白质过强度之间的关系:系统性审查
Federico Greco1, Luigi Giuseppe Quarta1, Paul M Parizel2
1Diagnostica Per Immagini Territoriale Aziendale, Cittadella Della Salute Azienda Sanitaria Locale Di Lecce, Piazza Filippo Bottazzi, Lecce, Italy.
Quantitative imaging in medicine and surgery
|November 16, 2023
概括
这篇评论将慢性病 (CKD) 与大脑中白质超强度 (WMH) 量的增加联系起来. 需要进一步的研究来了解这种脑血管损伤的潜在机制.
科学领域:
- 神经成像是一种神经成像.
- 腎臟病學 (nephrology) 是一種醫學專業.
- 脑血管疾病 脑血管疾病
背景情况:
- 慢性病 (CKD) 与各种系统性并发症有关.
- 在患有CKD的患者中,经常在脑MRI上观察到白质超强度 (WMH).
- 在CKD中对WMH的体积定量需要进一步调查.
研究的目的:
- 系统地审查和总结有关大脑MRI上白质超强度 (WMH) 的体积定量与慢性病 (CKD) 之间的关系的证据.
主要方法:
- 在2022年3月,在主要数据库 (MEDLINE PubMed Central,Scopus,Web of Science - Publons) 进行了全面的文献搜索.
- 文章的选择是基于WMH与CKD相关的定量体积评估.
- 严格的选过程排除了无关研究和缺乏体积WMH分析的研究.
主要成果:
- 最初的搜索产生了987篇文章,8篇最终在详细选后被纳入系统审查.
- 尽管方法异质,但包含的研究表明CKD和WMH体积增加之间存在关联.
- 由于非体积WMH分析,很大一部分最初识别的物品被排除在外.
结论:
- 有证据表明,慢性病与白质高强度体积之间存在联系.
- 可量化的生物标志物,如估计的淋巴细胞过率 (eGFR) 和尿中白蛋白与肌素比率 (UACR) 应纳入脑血管疾病研究.
- 需要进一步探索慢性功能衰竭中脑血管损伤的生物和分子机制.
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