在Furosemide之后的尿液定量测定严重急性损伤预测在重症儿童
Katja M Gist1, Jamie Penk2, Eric L Wald2
1Department of Pediatrics, Division of Pediatric Cardiology, University of Colorado, Children's Hospital Colorado, Aurora, Colorado, United States.
Journal of pediatric intensive care
|November 16, 2023
概括
二化物是一种化物.
科学领域:
- 儿科重症监护医学 儿科重症监护医学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
背景情况:
- 急性损伤 (AKI) 是重症儿童的一个重大问题.
- 严重AKI的预测标记对于及时干预至关重要.
- 罗塞米德的反应性在其他儿科和成人群体中显示出预测价值.
研究的目的:
- 调查furosemide反应是否预测心脏外科手术以外的危急儿童的严重AKI.
- 建立用于AKI预测的罗塞米德反应的定量测量.
主要方法:
- 在110名重症儿童的多中心回顾性研究中.
- 量化furosemide反应通过测量尿液流量 (mL/kg/小时) 0-6小时后剂量.
- 定义严重的AKI为病改善全球结果的2阶段或更大的7天内.
主要成果:
- 严重的AKI发生在20%的患者中.
- 较低的2小时 (<4毫升/千克/小时) 和6小时 (<3毫升/千克/小时) 的尿液流量与严重的AKI有显著的关联.
- 低2小时的尿流率增加了4.3倍的严重AKI的几率;低6小时的尿流率增加了6.19倍的几率.
结论:
- 尿液流速对富罗塞米德的反应是重症儿童严重AKI的重要预测因素.
- 量化评估罗塞米德的反应可以帮助早期发现AKI.
- 有必要进行前性研究来验证这些发现.
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