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儿童的海马体积注意力缺陷多动性障碍和言语和语言延迟的儿童

Vikas Dhikav¹, Manish Parakh², Kajal Pandey¹

¹Department of Health Research, Govt. of India, ICMR-NIIRNCD (Formerly Called as Desert Medicine Research Centre), Airforce Road, Jodhpur, Rajasthan, India.

Annals of Indian Academy of Neurology

|November 16, 2023

概括

患有注意力缺陷多动症 (ADHD) 的儿童表现出显著的海马缩. 这项研究使用MRI发现,与对照人群相比,儿科ADHD病例的海马体积减少了23%.

科学领域:

神经科学是一个神经科学.
儿科神经学儿科神经学
放射学放射学是一门学科.

背景情况:

海马是叶中的关键大脑结构,对认知功能至关重要.
新出现的证据将海马体异常与神经发育障碍联系在一起,包括注意力缺陷多动症 (ADHD).
患有多动症的儿童经常出现同时出现的言语和语言延迟,需要对潜在的神经相关性进行调查.

研究的目的:

在被诊断患有多动症的儿童中量化评估海马体体积差异.
使用先进的神经成像技术研究ADHD和海马体积之间的关系.
为了比较患有ADHD和言语/语言延迟的儿童的海马体积,与具有正常出生史的对照组进行比较.

主要方法:

磁共振成像 (MRI) 脑部扫描从12名ADHD儿童 (3-6岁) 和22名年龄相匹配的对照中获得.
用T1加权的斜冠状体序列进行详细的大脑成像.
使用Image-J软件手动对海马进行细分,以精确测量立方毫米 (mm3) 的体积.

主要成果:

患有多动症的儿童表现出明显减少的海马体积:右 (R) 2450.2 ± 667 mm3,左 (L) 2505.8 ± 878.5 mm3.
在ADHD组中,双边海马体的平均体积为2478±772.75mm3.
对照组的海马体积显著增加:R 3255.8 ± 1374.3 mm3,L 3159.3 ± 1451 mm3.

结论:

这项研究显示,与神经类型对照组相比,ADHD儿童的海马体积显著减少,约为23%.
这些发现表明,海马体结构变化可能是与儿童多动症相关的关键神经生物学特征.
需要进一步的研究来探索海马缩对儿科多动症认知缺陷和发育轨迹的影响.

关键词:

缩性缩症缩性缩症注意力缺陷多动性障碍注意力缺陷多动性障碍在海马体内,海马体

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