产前硫酸盐暴露对早产儿神经系统发育的长期影响
Le Zhou1, Xinghui Liu1, Xiaoli Yan2
1Obstetrics and Gynecology Department, West China Second University Hospital Sichuan University Chengdu China.
Food science & nutrition
|November 16, 2023
概括
在早产儿中,硫酸治疗可能会改善认知功能和大脑结构,使其更接近早产儿. 这表明,对早产婴儿的神经系统发育有潜在的益处.
科学领域:
- 神经科学是一个神经科学.
- 发育儿科 发育儿科
- 放射学 放射学是一门学科.
背景情况:
- 过早出生 (PTB) 儿童往往表现出神经发育的差异,与期生 (TB) 儿童相比.
- 硫酸有时给那些有早产风险的孕妇服用.
- 了解硫酸对PTB儿童大脑发育的影响至关重要.
研究的目的:
- 调查硫酸治疗对灰质体积 (GMV) 和PTB儿童认知功能的影响.
- 为了比较PTB儿童与没有硫酸盐暴露和结核病儿童之间的大脑结构和智力得分.
主要方法:
- 结构磁共振成像 (MRI) 用于分析51名儿童 (28 PTB, 23 TB) 的GMV.
- 使用SPM8进行全脑克素智能分析,以确定GMV的群体差异.
- 智力尺度 (口头和全尺度智商) 在10-16岁的校正年龄下进行.
主要成果:
- 没有的PTB儿童的智商比结核病儿童要低得多.
- 带有的PTB儿童的智商几乎与结核病儿童相同.
- 在PTB儿童中观察到左直和左下额中减少的GMV,当被管理时,体积更接近TB儿童.
结论:
- 大脑结构异常,特别是左直环和左下额头环中的减少的GMV,存在于PTB儿童中.
- 硫酸治疗似乎与改善PTB儿童的认知功能和大脑结构有关,接近TB儿童的水平.
- 在怀孕期间早期启动硫酸治疗时,与左下额头瘤 (GMV) 有负相关性.
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