骨髓移植前肺功能测试在预测移植后非传染性肺部并发症中的作用
Amani S Ahmed1, Roaa S Gassas1, Mohamed E Ahmed2,3
1Department of Adult Hematology/Bone Marrow Transplant Section, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Jeddah, Saudi Arabia.
Saudi journal of medicine & medical sciences
|November 16, 2023
概括
肺功能测试 (PFT) 可以预测骨髓移植 (BMT) 后的并发症. 在自身的 BMT 中,强迫生命能力降低 (<80%) 和移植前辐射预测问题,突出了 PFT.
科学领域:
- 血液学 血液学 血液学
- 肺部病理学 肺部病理学
- 在瘤学瘤学.
背景情况:
- 肺功能测试 (PFT) 对于移植前的风险评估和移植后的结果预测至关重要.
- 在沙特骨髓移植 (BMT) 患者中对PFT存在有限的研究.
- 增加良性和恶性疾病的BMT需要对当地实践进行评估.
研究的目的:
- 评估PFTs在沙特患者预测BMT后肺部并发症中的作用.
- 为了确定患者相关的风险因素,与肺部并发症相关的后 BMT.
- 在BMT的背景下评估当地PFT实践.
主要方法:
- 在吉达的Noorah公主瘤中心对成年BMT患者 (2014-2020) 的回顾性队列研究.
- 分析患者相关的风险因素和肺部并发症的发生率.
- 自异性和异性 BMT 组之间的比较.
主要成果:
- 包括186名患者:143名自主,43名异性.
- 在自身的BMT中,强迫生命能力<80%显著预测了BMT后的肺部并发症 (P=0.012).
- 肺部干扰和移植前辐射与自身组的呼吸困扰有关.
结论:
- 强迫性生命能力<80%是自性BMT非传染性并发症的重要预测因素.
- 肺部参与和移植前辐射是肺部并发症的关键患者相关因素.
- 调查结果强调了PFT在 BMT风险分层中的重要性.
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