幽默和细胞因素在生长期间抑制酸盐诱导的血管化
Yuki Kamei1,2, Yosuke Okumura1, Yuichiro Adachi1
1Department of Clinical Nutrition and Food Management, Tokushima University Graduate School of Medical Nutrition, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan.
Journal of clinical biochemistry and nutrition
|November 16, 2023
概括
成长中的小鼠由于高的fetuin-A和低的组织非特异性性酸酶 (TNAP) 水平而抵抗血管化. 这表明在发育过程中对高酸盐水平的保护性防御系统.
科学领域:
- 心血管生物学 心血管生物学
- 腎臟病學 (nephrology) 是一種醫學專業.
- 发展生物学 发展生物学
背景情况:
- 高酸血是慢性病 (CKD) 患者心血管疾病和死亡的一个关键风险因素.
- 过高的无机酸盐 (Pi) 诱导血管化,但机制尚不清楚.
- 成长中的个体具有高的Pi水平,而没有典型的血管化,这表明发展性抵抗.
研究的目的:
- 研究在发育过程中对酸盐诱导的血管化的防御系统的存在和机制.
- 为了比较年轻与成年小鼠血清和大动脉对高酸盐的反应中的化倾向.
主要方法:
- 年轻 (3周大) 和成年 (10个月大) 小鼠血清中化倾向的比较.
- 在高无机酸盐 (Pi) 介质中体外培养年轻和成年老鼠大动脉.
- 在培养的大动脉中分析组织非特异性性酸酶 (TNAP) 的mRNA水平.
主要成果:
- 年轻人血清的化倾向明显低于成年人血清,可能是由于较高的fetuin-A水平.
- 成年主动脉在高Pi介质中显示出明显的化,而年轻主动脉则没有.
- 高Pi介质仅在成年主动脉中增加了TNAPmRNA水平,这表明年轻主动脉中抑制了酸盐降解.
结论:
- 在成长中的小鼠中,大动脉抵抗Pi诱导的血管化.
- 这种耐药性归因于高血清fetuin-A水平和在发育过程中抑制的TNAP表达.
- 这些发现突出了年轻人对血管化的保护机制.
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