装有乙醇胺的银纳米颗粒:一种潜在的治疗小鼠三病的方法
E F Abdel Hamed1, A A Taha1, S M Abdel Ghany1
1Department of Medical Parasitology, Faculty of Medicine, Zagazig University, Sharkia, Egypt.
Journal of helminthology
|November 16, 2023
概括
含有乙胺的银纳米颗粒 (AgNPs) 在治疗食物传播的寄生虫疾病 - - 三病方面表现有前途. 这种新疗法有效地减少了寄生虫负载,并恢复了受感染小鼠的组织健康.
科学领域:
- 寄生虫学的寄生虫学
- 纳米技术纳米技术
- 食物传播疾病 食物传播疾病
背景情况:
- 三病是一种全球性由食物传播的寄生虫疾病,由*Trichinella*线虫引起.
- 目前针对三病的治疗方法有限,往往无效,并伴有不良影响.
- 对于新,安全和有效的治疗策略有着至关重要的需求.
研究的目的:
- 为了评估阿扎胺载入的银纳米粒子 (AgNPs) 对小鼠三病的治疗疗效.
- 评估这种新型治疗对寄生虫负担,氧化应激和组织损伤的影响.
主要方法:
- 50只男性瑞士白色老鼠被T. spiralis幼虫感染.
- 小鼠被分为五组:对照组,仅感染的小鼠,感染AgNPs的小鼠,感染acetazolamide的小鼠,感染充满acetazolamide的AgNP的小鼠.
- 通过寄生虫数量 (成人和幼虫),血清抗氧化能力以及基因病学/超结构分析来衡量有效性.
主要成果:
- 装有乙胺的AgNP在肠道成年人 (84.72%) 和肌肉幼虫 (80.74%) 中显示出最大的减少.
- 这个群体表现出优越的抗氧化能力,减轻氧化应激和减少组织损伤.
- 组织病理学检查显示,正常组织结构的恢复和炎症的减少.
结论:
- 含有乙胺的AgNP代表了对T. spiralis*感染的有前途的治疗剂.
- 治疗有效地减少了寄生虫负载,并减轻了病理损伤.
- 这种基于纳米技术的方法在治疗三病方面提供了潜在的进步.
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