严重高胆固醇血症患者的长期死亡率来自美国种族和种族多样性队列
Jeremy Miles1, Andrea Scotti1, Francesco Castagna1
1Cardiology Division, Montefiore Healthcare Network/Albert Einstein College of Medicine, Bronx, NY (J.M., A.S., F.C., T.K., P.P.L., A.C., S.L., A.L., M.J.G., C.J.R., L.S.).
Circulation
|November 16, 2023
概括
在多样化的美国队列中确定了严重高胆固醇血症 (低密度脂蛋白胆固醇≥190 mg/ dL) 死亡率的预测因素. 随着时间的推移,他类药物的使用量有所下降,这凸显了对高危人群的持续治疗和早期诊断的需要.
科学领域:
- 心脏病学
- 公共卫生
- 流行病学
背景情况:
- 预测严重高胆固醇血症 (低密度脂蛋白胆固醇≥190 mg/dL) 的死亡率的工具有限,特别是在多样化的群体中.
- 这项研究旨在更好地了解严重高胆固醇血症的多民族美国患者队列中的死亡率预测因素.
研究的目的:
- 在一个具有低密度脂蛋白胆固醇≥190 mg/ dL的多元美国患者队列中评估长期全因死亡率的预测因素.
- 分析严重高胆固醇血症患者使用他类药物的趋势.
主要方法:
- 从2010年至2020年对18740名低密度脂蛋白胆固醇≥190 mg/dL的患者进行了回顾性分析.
- 不包括18岁以下或有恶性病的患者.
- 根据人口,临床和治疗变量调整的考克斯回归分析;按年龄,性别,种族/民族和预防状况分层.
主要成果:
- 较高的低密度脂蛋白胆固醇和甘油三与9年死亡风险的增加有关.
- 与较高死亡率相关的临床因素包括男性性别,年龄,高血压,慢性病,糖尿病,心力衰竭,心肌梗塞和低体重指数.
- 降脂疗法为生存提供了益处,而他类药物的使用随着时间的推移而减少,特别是在初级预防中.
结论:
- 一些患者特征预测严重高胆固醇血症的死亡率在美国人口中增加.
- 观察到减少他类药物的使用趋势令人担忧,特别是在初级预防方面.
- 这些发现强调了早期识别和持续治疗严重高胆固醇血症的重要性,以改善长期结果.
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