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使用DNA修复基因表达的CHO细胞系稳定性的预测

Lauren T Cordova1, Hussain Dahodwala1,2, Rebecca Cooley3

  • 1Department of Chemical and Biomolecular Engineering, University of Delaware, Newark, Delaware, USA.

Biotechnology journal
|November 16, 2023
PubMed
概括

像Lig4和Xrcc6这样的DNA修复基因可能会预测中国仓鼠卵巢 (CHO) 细胞系的稳定性. 老细胞表达率较低表明潜在的生产不稳定性,有助于生物制药制造.

关键词:
在CHO细胞中.由于CHO生产的不稳定性.在Lig4中使用Lig4.Xrcc6 的时间.生物标志物 生物标志物生物制药制品 生物制药制品生物过程开发开发生物工艺工程是生物工艺工程.

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