用腹腔透析治疗的AKI儿童的蛋白质损失和葡萄糖吸收
Peter Nourse1, Mignon McCulloch1, Ashton Coetzee1
1Division of Pediatric Nephrology, Department of Paediatrics and Child Health, Red Cross War Memorial Children's Hospital, University of Cape Town, South Africa.
概括
接受急性腹膜透析 (PD) 的儿童经历了显著的蛋白质损失和葡萄糖吸收. 连续流PD显示比传统PD更高的蛋白质损失,影响急性损伤 (AKI) 的营养管理.
科学领域:
- 儿科脏病学 儿科脏病学
- 脏营养 脏营养
- 透析治疗 透析治疗
背景情况:
- 精确评估蛋白质损失和葡萄糖吸收对于接受腹腔透析 (PD) 的急性损伤 (AKI) 儿童的营养管理至关重要.
- 有限的数据存在关于这些参数在PD的儿科AKI患者.
- 本研究通过对现有试验数据的二次分析来解决这一差距.
研究的目的:
- 量化和比较葡萄糖吸收和蛋白质 (白蛋白) 输入透析剂的儿童与AKI在传统PD与连续流PD (CFPD).
- 探索白蛋白损失,葡萄糖吸收和其他患者/透析因素之间的相关性.
主要方法:
- 一个交叉随机对照试验的二次分析,涉及15名患有AKI的儿童.
- 传统PD和CFPD之间的透析白蛋白损失和葡萄糖吸收的比较.
- 分析了白蛋白损失,葡萄糖吸收,超和患者/透析变量之间的相关性.
主要成果:
- 常规PD的平均每日白蛋白损失为0.3g/kg,CFPD的平均每日白蛋白损失为0.56g/kg.
- 常规PD的平均每日葡萄糖吸收量为4.67g/kg,CFPD的平均每日吸收量为3.85g/kg.
- 在CFPD (R=0.61,p=0.02) 期间观察到超过和白蛋白损失之间的中等相关性. 在PD模式之间没有发现葡萄糖吸收或白蛋白损失的显著差异,尽管这项研究没有为此提供动力.
结论:
- 在PD的AKI儿童中,蛋白质损失和葡萄糖吸收是相当大的,需要在营养处方中考虑.
- 与传统PD相比,CFPD的蛋白质损失显著更高.
- 这些发现强调了为接受透析的儿科AKI患者提供量身定制的营养支持的重要性.
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