宫脊髓形态与多发性硬化症患者的临床残疾之间的关系
Nihal Gurlek Celik1, Ahmet Kagan Karabulut2, Zeliha Fazliogullari2
1Amasya University, Faculty of Medicine, Department of Anatomy - Amasya, Turkey.
Revista da Associacao Medica Brasileira (1992)
|November 16, 2023
概括
椎脊髓缩与多发性硬化症 (MS) 患者的临床残疾增加有关. 减少脊髓区域与MS中更高的扩大残疾状态量表得分相关.
科学领域:
- 神经科学是一个神经科学.
- 放射学 放射学是一门学科.
- 免疫学 免疫学 免疫学
背景情况:
- 多发性硬化症 (MS) 是一种影响中枢神经系统的自身免疫性疾病.
- 宫脊髓在MS中经常受到影响,导致神经系统缺陷.
研究的目的:
- 调查宫脊髓缩和MS患者临床残疾之间的关联.
- 量化MS患者的椎脊髓尺寸,并将其与健康对照进行比较.
主要方法:
- 用T2权重磁共振成像 (MRI) 来评估64名多发性硬化患者和64名对照患者的椎脊髓截面面积.
- 测量包括C2-3,C3-4,C4-5,C5-6,C6-7等级的轴面积.
主要成果:
- 与对照组相比,MS患者的椎脊髓表面积在C2-3,C3-4,C4-5和C6-7显著降低 (p<0.05).
- 在C4-5,C5-6,C6-7水平 (p<0.05) 上观察到扩展残疾状况量表 (EDSS) 评分和椎脊髓缩之间存在负相关性.
结论:
- 椎脊髓缩是MS的一个可测量的特征.
- 椎脊髓缩的程度与更大的临床残疾有显著的关联,MS患者的EDSS得分更高表明了这一点.
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