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Updated: Jun 16, 2026

Mass Spectrometry and Luminogenic-based Approaches to Characterize Phase I Metabolic Competency of In Vitro Cell Cultures
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Published on: March 28, 2017

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索拉尼丁作为食衍生的CYP2D6活体活性标记物的营养测量验证

Julian Peter Müller1, Jens Sarömba1, Patrick Ziegler2

  • 1Institute of Clinical Pharmacology, University Hospital of RWTH Aachen, Aachen, Germany.

Clinical pharmacology and therapeutics
|November 16, 2023
PubMed
概括

索拉尼丁代谢物,特别是3,4-秒索拉尼丁-3,4-二氧酸 (SSDA),表现出稳定的个体内变异性,可以作为细胞染色体P450 2D6 (CYP2D6) 活性的可靠标志物. 这种饮食标记与美托普罗罗尔的表型学相关性很好,验证了其用于预测CYP2D6表型的使用.

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